Carbonic Anhydrase, Diuretics and Egg Shell Formation
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Effect of Carbonic Anhydrase , Na ' - H + Exchange Inhibitors and the Loop Diuretics Furosemide and
We microperfused the loop of Henle (LOH) to assess its contribution to urine acidification in vivo. Under control conditions (Na HCO3= 13 mM, perfusion rate 17 nl/min-') net bicarbonate transport (JHCO-) was unsaturated, flowand concentration-dependent, and increased linearly until a bicarbonate load of 1,400 pmols minwas reached. Methazolamide (2-10-4 M) reduced JHCO3 by 70%; the amiloride ana...
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Investigations of the rapid enzyme carbonic anhydrase have now been extended by crystallographic analysis at high CO2 pressures to examine the movements of water molecules in different steps of the catalysis. The rate of catalysis seems well explained by the assembled observations.
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Davenport and Fisher (1938) reported the discovery DOGS P School of Medicine of large amounts of carbonic anhydrase in the gastric mucosa of cats, rats and rabbits. Davenport (1939) demonstrated that carbonic anhydrase is present in high concentration in the parietal cells and in lower concentration in the cells of the surface epithelium of the gastric mucosa of cats and rats. When those invest...
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Carbonic anhydrase (CA; EC 4.2.1.1) is a zinc metalloenzyme catalysing the reversible hydration of CO2 to produce H+ and HCO3−. Its activity is virtually ubiquitous in nature. The fundamental role of this biochemical reaction in diverse biological systems has driven the evolution of several distinct and unrelated families of CAs. Five CA families, referred as ┙-, ┚-, ┛-CA, ├, and ζ-CAs have bee...
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3. Arch. d'Ophtal., Vol. LIII, p. 166, 1936. 4. WEEKERS, L. and FANCHAMPS, J.-Arch. d'Ophtal., Vol. I, p. 585. 1937. 5. WEEKERS, L.-Bull; Soc. Ophtal , Paris. Nancy, 16 juin, sdance consacr6e au traitement mddical du glaucome. 1939. 6. WEEKERS, L. and BONHOMME, F.-Obhthalmologica, Vol. XCIX, p. 180, 1940. 7. WEEKERS, L.-Bull. Soc. belge d'O5htal., fdvrier, 1948. 8. WEEKERS, R. and HEINTZ, A.-Bu...
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ژورنال
عنوان ژورنال: Poultry Science
سال: 1962
ISSN: 0032-5791
DOI: 10.3382/ps.0411792